A reversible haploid mouse embryonic stem cell biobank resource for functional genomics

Ulrich Elling (), Reiner A. Wimmer, Andreas Leibbrandt, Thomas Burkard, Georg Michlits, Alexandra Leopoldi, Thomas Micheler, Dana Abdeen, Sergei Zhuk, Irene M. Aspalter, Cornelia Handl, Julia Liebergesell, Maria Hubmann, Anna-Maria Husa, Manuela Kinzer, Nicole Schuller, Ellen Wetzel, Nina van de Loo, Jorge Arturo Zepeda Martinez, David Estoppey, Ralph Riedl, Fengtang Yang, Beiyuan Fu, Thomas Dechat, Zoltán Ivics, Chukwuma A. Agu, Oliver Bell, Dieter Blaas, Holger Gerhardt, Dominic Hoepfner, Alexander Stark and Josef M. Penninger ()
Additional contact information
Ulrich Elling: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Reiner A. Wimmer: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Andreas Leibbrandt: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Thomas Burkard: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Georg Michlits: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Alexandra Leopoldi: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Thomas Micheler: Vienna Biocenter Core Facilities, Vienna Biocenter (VBC)
Dana Abdeen: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Sergei Zhuk: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Irene M. Aspalter: MRC Laboratory for Molecular Cell Biology and Institute for the Physics of Living Systems, University College London
Cornelia Handl: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Julia Liebergesell: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Maria Hubmann: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Anna-Maria Husa: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Manuela Kinzer: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Nicole Schuller: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Ellen Wetzel: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Nina van de Loo: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Jorge Arturo Zepeda Martinez: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
David Estoppey: Novartis Institutes for BioMedical Research
Ralph Riedl: Novartis Institutes for BioMedical Research
Fengtang Yang: Wellcome Trust Sanger Institute
Beiyuan Fu: Wellcome Trust Sanger Institute
Thomas Dechat: Max F. Perutz Laboratories, Medical University of Vienna
Zoltán Ivics: Paul Ehrlich Institut
Chukwuma A. Agu: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Oliver Bell: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)
Dieter Blaas: Max F. Perutz Laboratories, Medical University of Vienna
Holger Gerhardt: Max-Delbrück Center for Molecular Medicine in the Helmholtz Association
Dominic Hoepfner: Novartis Institutes for BioMedical Research
Alexander Stark: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
Josef M. Penninger: Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC)

Nature, 2017, vol. 550, issue 7674, 114-118

Abstract: The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to search for genes that are required for rhinovirus infection and angiogenesis using forward and reverse genetic screens, respectively.

Date: 2017
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DOI: 10.1038/nature24027

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