CG dinucleotide suppression enables antiviral defence targeting non-self RNA

Matthew A. Takata, Daniel Gonçalves-Carneiro, Trinity M. Zang, Steven J. Soll, Ashley York, Daniel Blanco-Melo and Paul D. Bieniasz ()
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Matthew A. Takata: Laboratory of Retrovirology, The Rockefeller University
Daniel Gonçalves-Carneiro: Laboratory of Retrovirology, The Rockefeller University
Trinity M. Zang: Laboratory of Retrovirology, The Rockefeller University
Steven J. Soll: Laboratory of Retrovirology, The Rockefeller University
Ashley York: Laboratory of Retrovirology, The Rockefeller University
Daniel Blanco-Melo: Laboratory of Retrovirology, The Rockefeller University
Paul D. Bieniasz: Laboratory of Retrovirology, The Rockefeller University

Nature, 2017, vol. 550, issue 7674, 124-127

Abstract: Vertebrate genomes contain fewer CG dinucleotides than would be expected by chance, and this pattern is mimicked by many viruses; HIV-1 derivatives mutated to contain more CG dinucleotides are targeted by the human antiviral protein ZAP, suggesting that CG suppression has evolved in viruses to evade recognition.

Date: 2017
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DOI: 10.1038/nature24039

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