TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

Manoël Prouteau, Ambroise Desfosses, Christian Sieben, Clélia Bourgoint, Nour Lydia Mozaffari, Davide Demurtas, Alok K. Mitra, Paul Guichard, Suliana Manley and Robbie Loewith ()
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Manoël Prouteau: University of Geneva
Ambroise Desfosses: School of Biological Sciences, University of Auckland
Christian Sieben: Institute of Physics, Laboratory of Experimental Biophysics, École Polytechnique Fédérale de Lausanne (EPFL)
Clélia Bourgoint: University of Geneva
Nour Lydia Mozaffari: University of Geneva
Davide Demurtas: Interdisciplinary Centre for Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL)
Alok K. Mitra: School of Biological Sciences, University of Auckland
Paul Guichard: University of Geneva
Suliana Manley: Institute of Physics, Laboratory of Experimental Biophysics, École Polytechnique Fédérale de Lausanne (EPFL)
Robbie Loewith: University of Geneva

Nature, 2017, vol. 550, issue 7675, 265-269

Abstract: In budding yeast, glucose withdrawal, via the Rag GTPases, leads to TORC1 inhibition through its re-organization into a giant, vacuole-associated helix named a TOROID (TORC1 organized in inhibited domain).

Date: 2017
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DOI: 10.1038/nature24021

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