Cancer drug addiction is relayed by an ERK2-dependent phenotype switch

Xiangjun Kong, Thomas Kuilman, Aida Shahrabi, Julia Boshuizen, Kristel Kemper, Ji-Ying Song, Hans W. M. Niessen, Elisa A. Rozeman, Marnix H. Geukes Foppen, Christian U. Blank and Daniel S. Peeper ()
Additional contact information
Xiangjun Kong: The Netherlands Cancer Institute
Thomas Kuilman: The Netherlands Cancer Institute
Aida Shahrabi: The Netherlands Cancer Institute
Julia Boshuizen: The Netherlands Cancer Institute
Kristel Kemper: The Netherlands Cancer Institute
Ji-Ying Song: The Netherlands Cancer Institute
Hans W. M. Niessen: VU University Medical Center, ACS
Elisa A. Rozeman: The Netherlands Cancer Institute
Marnix H. Geukes Foppen: The Netherlands Cancer Institute
Christian U. Blank: The Netherlands Cancer Institute
Daniel S. Peeper: The Netherlands Cancer Institute

Nature, 2017, vol. 550, issue 7675, 270-274

Abstract: The identification of an ERK2–JUNB–FRA1 signalling pathway that drives addiction to therapeutic drugs in cancer cells, and an ERK2-dependent phenotype switch that precedes cell death after drug withdrawal, may help to guide therapies that exploit the addiction phenotype.

Date: 2017
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DOI: 10.1038/nature24037

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