Dynamic landscape and regulation of RNA editing in mammals

Meng How Tan (), Qin Li, Raghuvaran Shanmugam, Robert Piskol, Jennefer Kohler, Amy N. Young, Kaiwen Ivy Liu, Rui Zhang, Gokul Ramaswami, Kentaro Ariyoshi, Ankita Gupte, Liam P. Keegan, Cyril X. George, Avinash Ramu, Ni Huang, Elizabeth A. Pollina, Dena S. Leeman, Alessandra Rustighi, Y. P. Sharon Goh, Ajay Chawla, Giannino Del Sal, Gary Peltz, Anne Brunet, Donald F. Conrad, Charles E. Samuel, Mary A. O’Connell, Carl R. Walkley, Kazuko Nishikura and Jin Billy Li ()
Additional contact information
Meng How Tan: Stanford University School of Medicine
Qin Li: Stanford University School of Medicine
Raghuvaran Shanmugam: School of Chemical and Biomedical Engineering, Nanyang Technological University
Robert Piskol: Stanford University School of Medicine
Jennefer Kohler: Stanford University School of Medicine
Amy N. Young: Stanford University School of Medicine
Kaiwen Ivy Liu: Genome Institute of Singapore, Agency for Science Technology and Research
Rui Zhang: Stanford University School of Medicine
Gokul Ramaswami: Stanford University School of Medicine
Kentaro Ariyoshi: The Wistar Institute
Ankita Gupte: St Vincent’s Institute of Medical Research
Liam P. Keegan: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Cyril X. George: Cellular and Developmental Biology, University of California-Santa Barbara
Avinash Ramu: Washington University School of Medicine
Ni Huang: Washington University School of Medicine
Elizabeth A. Pollina: Stanford University School of Medicine
Dena S. Leeman: Stanford University School of Medicine
Alessandra Rustighi: University of Trieste, 34127 Trieste, Italy and National Laboratory CIB (LNCIB)
Y. P. Sharon Goh: Cardiovascular Research Institute, University of California-San Francisco
Ajay Chawla: Cardiovascular Research Institute, University of California-San Francisco
Giannino Del Sal: University of Trieste, 34127 Trieste, Italy and National Laboratory CIB (LNCIB)
Gary Peltz: Stanford University School of Medicine
Anne Brunet: Stanford University School of Medicine
Donald F. Conrad: Washington University School of Medicine
Charles E. Samuel: Cellular and Developmental Biology, University of California-Santa Barbara
Mary A. O’Connell: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Carl R. Walkley: St Vincent’s Institute of Medical Research
Kazuko Nishikura: The Wistar Institute
Jin Billy Li: Stanford University School of Medicine

Nature, 2017, vol. 550, issue 7675, 249-254

Abstract: Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

Date: 2017
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DOI: 10.1038/nature24041

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