Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Jer-Yuan Hsu (), Suzanne Crawley, Michael Chen, Dina A. Ayupova, Darrin A. Lindhout, Jared Higbee, Alan Kutach, William Joo, Zhengyu Gao, Diana Fu, Carmen To, Kalyani Mondal, Betty Li, Avantika Kekatpure, Marilyn Wang, Teresa Laird, Geoffrey Horner, Jackie Chan, Michele McEntee, Manuel Lopez, Damodharan Lakshminarasimhan, Andre White, Sheng-Ping Wang, Jun Yao, Junming Yie, Hugo Matern, Mark Solloway, Raj Haldankar, Thomas Parsons, Jie Tang, Wenyan D. Shen, Yu Alice Chen, Hui Tian and Bernard B. Allan ()
Additional contact information
Jer-Yuan Hsu: NGM Biopharmaceuticals
Suzanne Crawley: NGM Biopharmaceuticals
Michael Chen: NGM Biopharmaceuticals
Dina A. Ayupova: NGM Biopharmaceuticals
Darrin A. Lindhout: NGM Biopharmaceuticals
Jared Higbee: NGM Biopharmaceuticals
Alan Kutach: NGM Biopharmaceuticals
William Joo: NGM Biopharmaceuticals
Zhengyu Gao: NGM Biopharmaceuticals
Diana Fu: NGM Biopharmaceuticals
Carmen To: NGM Biopharmaceuticals
Kalyani Mondal: NGM Biopharmaceuticals
Betty Li: NGM Biopharmaceuticals
Avantika Kekatpure: NGM Biopharmaceuticals
Marilyn Wang: NGM Biopharmaceuticals
Teresa Laird: NGM Biopharmaceuticals
Geoffrey Horner: NGM Biopharmaceuticals
Jackie Chan: NGM Biopharmaceuticals
Michele McEntee: NGM Biopharmaceuticals
Manuel Lopez: NGM Biopharmaceuticals
Damodharan Lakshminarasimhan: XTAL Biostructures
Andre White: XTAL Biostructures
Sheng-Ping Wang: Merck Research Labs
Jun Yao: Merck Research Labs
Junming Yie: Merck Research Labs
Hugo Matern: NGM Biopharmaceuticals
Mark Solloway: NGM Biopharmaceuticals
Raj Haldankar: NGM Biopharmaceuticals
Thomas Parsons: NGM Biopharmaceuticals
Jie Tang: NGM Biopharmaceuticals
Wenyan D. Shen: NGM Biopharmaceuticals
Yu Alice Chen: NGM Biopharmaceuticals
Hui Tian: NGM Biopharmaceuticals
Bernard B. Allan: NGM Biopharmaceuticals

Nature, 2017, vol. 550, issue 7675, 255-259

Abstract: GDNF receptor alpha-like is a brainstem-restricted receptor for growth and differentiation factor 15, regulating appetite and body weight in non-homeostatic conditions by activating the emergency circuit response to disease and toxin stresses.

Date: 2017
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DOI: 10.1038/nature24042

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