Hippo pathway deficiency reverses systolic heart failure after infarction

John P. Leach, Todd Heallen, Min Zhang, Mahdis Rahmani, Yuka Morikawa, Matthew C. Hill, Ana Segura, James T. Willerson and James F. Martin ()
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John P. Leach: Baylor College of Medicine, One Baylor Plaza
Todd Heallen: The Texas Heart Institute
Min Zhang: Baylor College of Medicine, One Baylor Plaza
Mahdis Rahmani: The Texas Heart Institute
Yuka Morikawa: The Texas Heart Institute
Matthew C. Hill: Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza
Ana Segura: The Texas Heart Institute
James T. Willerson: The Texas Heart Institute
James F. Martin: Baylor College of Medicine, One Baylor Plaza

Nature, 2017, vol. 550, issue 7675, 260-264

Abstract: Deletion of the Hippo pathway component Salvador in mouse hearts with established ischaemic heart failure after myocardial infarction induces a reparative genetic program with increased scar border vascularity, reduced fibrosis, and recovery of pumping function.

Date: 2017
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DOI: 10.1038/nature24045

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