RNA targeting with CRISPR–Cas13

Omar O. Abudayyeh, Jonathan S. Gootenberg, Patrick Essletzbichler, Shuo Han, Julia Joung, Joseph J. Belanto, Vanessa Verdine, David B. T. Cox, Max J. Kellner, Aviv Regev, Eric S. Lander, Daniel F. Voytas, Alice Y. Ting and Feng Zhang ()
Additional contact information
Omar O. Abudayyeh: Broad Institute of MIT and Harvard
Jonathan S. Gootenberg: Broad Institute of MIT and Harvard
Patrick Essletzbichler: Broad Institute of MIT and Harvard
Shuo Han: Biology, and Chemistry, Stanford University
Julia Joung: Broad Institute of MIT and Harvard
Joseph J. Belanto: Cell Biology and Development, University of Minnesota
Vanessa Verdine: Broad Institute of MIT and Harvard
David B. T. Cox: Broad Institute of MIT and Harvard
Max J. Kellner: Broad Institute of MIT and Harvard
Aviv Regev: Broad Institute of MIT and Harvard
Eric S. Lander: Broad Institute of MIT and Harvard
Daniel F. Voytas: Cell Biology and Development, University of Minnesota
Alice Y. Ting: Biology, and Chemistry, Stanford University
Feng Zhang: Broad Institute of MIT and Harvard

Nature, 2017, vol. 550, issue 7675, 280-284

Abstract: The class 2 type VI RNA-guided RNA-targeting CRISPR–Cas effector Cas13 can be engineered for RNA knockdown and binding, expanding the CRISPR toolset with a flexible platform for studying RNA in mammalian cells and therapeutic development.

Date: 2017
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DOI: 10.1038/nature24049

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