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Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

Qingfeng Chen, Ji She, Weizhong Zeng, Jiangtao Guo, Haoxing Xu, Xiao-chen Bai () and Youxing Jiang ()
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Qingfeng Chen: University of Texas Southwestern Medical Center
Ji She: University of Texas Southwestern Medical Center
Weizhong Zeng: University of Texas Southwestern Medical Center
Jiangtao Guo: University of Texas Southwestern Medical Center
Haoxing Xu: Cellular, and Developmental Biology, University of Michigan
Xiao-chen Bai: University of Texas Southwestern Medical Center
Youxing Jiang: University of Texas Southwestern Medical Center

Nature, 2017, vol. 550, issue 7676, 415-418

Abstract: The structure of mouse transient receptor potential mucolipin 1 (TRPML1), a cation channel located within endosomal and lysosomal membranes, is resolved using single-particle electron cryo-microscopy.

Date: 2017
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DOI: 10.1038/nature24035

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