Cytoplasmic chromatin triggers inflammation in senescence and cancer

Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J. Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou, Brian C. Capell, Caiyue Xu, Mingang Xu, Julia E. Kieckhaefer, Tianying Jiang, Michal Shoshkes-Carmel, K. M. Ahasan Al Tanim, Glen N. Barber, John T. Seykora, Sarah E. Millar, Klaus H. Kaestner, Benjamin A. Garcia, Peter D. Adams () and Shelley L. Berger ()
Additional contact information
Zhixun Dou: Perelman School of Medicine, University of Pennsylvania
Kanad Ghosh: Perelman School of Medicine, University of Pennsylvania
Maria Grazia Vizioli: Beatson Institute for Cancer Research
Jiajun Zhu: Perelman School of Medicine, University of Pennsylvania
Payel Sen: Perelman School of Medicine, University of Pennsylvania
Kirk J. Wangensteen: University of Pennsylvania
Johayra Simithy: Perelman School of Medicine, University of Pennsylvania
Yemin Lan: Perelman School of Medicine, University of Pennsylvania
Yanping Lin: Perelman School of Medicine, University of Pennsylvania
Zhuo Zhou: Biodynamic Optical Imaging Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University
Brian C. Capell: Perelman School of Medicine, University of Pennsylvania
Caiyue Xu: Perelman School of Medicine, University of Pennsylvania
Mingang Xu: Perelman School of Medicine, University of Pennsylvania
Julia E. Kieckhaefer: University of Pennsylvania
Tianying Jiang: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Michal Shoshkes-Carmel: University of Pennsylvania
K. M. Ahasan Al Tanim: Perelman School of Medicine, University of Pennsylvania
Glen N. Barber: University of Miami Miller School of Medicine
John T. Seykora: Perelman School of Medicine, University of Pennsylvania
Sarah E. Millar: Perelman School of Medicine, University of Pennsylvania
Klaus H. Kaestner: University of Pennsylvania
Benjamin A. Garcia: Perelman School of Medicine, University of Pennsylvania
Peter D. Adams: Beatson Institute for Cancer Research
Shelley L. Berger: Perelman School of Medicine, University of Pennsylvania

Nature, 2017, vol. 550, issue 7676, 402-406

Abstract: Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

Date: 2017
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DOI: 10.1038/nature24050

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