Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Alexander A. Sousa, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz and Jennifer A. Doudna ()
Additional contact information
Janice S. Chen: University of California
Yavuz S. Dagdas: Biophysics Graduate Group, University of California
Benjamin P. Kleinstiver: Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital
Moira M. Welch: Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital
Alexander A. Sousa: Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital
Lucas B. Harrington: University of California
Samuel H. Sternberg: University of California
J. Keith Joung: Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital
Ahmet Yildiz: University of California
Jennifer A. Doudna: University of California

Nature, 2017, vol. 550, issue 7676, 407-410

Abstract: A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.

Date: 2017
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DOI: 10.1038/nature24268

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