DNA sequencing at 40: past, present and future

Jay Shendure (), Shankar Balasubramanian, George M. Church, Walter Gilbert, Jane Rogers, Jeffery A. Schloss and Robert H. Waterston
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Jay Shendure: University of Washington
Shankar Balasubramanian: University of Cambridge
George M. Church: Harvard Medical School
Walter Gilbert: Harvard University
Jane Rogers: International Wheat Genome Sequencing Consortium
Jeffery A. Schloss: National Human Genome Research Institute, National Institutes of Health
Robert H. Waterston: University of Washington

Nature, 2017, vol. 550, issue 7676, 345-353

Abstract: Abstract This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has been extensively and creatively repurposed, including as a ‘counter’ for a vast range of molecular phenomena. We predict that in the long view of history, the impact of DNA sequencing will be on a par with that of the microscope.

Date: 2017
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DOI: 10.1038/nature24286

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