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Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

Thiet M. Vu, Ayako-Nakamura Ishizu, Juat Chin Foo, Xiu Ru Toh, Fangyu Zhang, Ding Ming Whee, Federico Torta, Amaury Cazenave-Gassiot, Takayoshi Matsumura, Sangho Kim, Sue-Anne E. S. Toh, Toshio Suda, David L. Silver, Markus R. Wenk and Long N. Nguyen ()
Additional contact information
Thiet M. Vu: Yong Loo Lin School of Medicine, National University of Singapore
Ayako-Nakamura Ishizu: Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore
Juat Chin Foo: Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore
Xiu Ru Toh: Yong Loo Lin School of Medicine, National University of Singapore
Fangyu Zhang: Yong Loo Lin School of Medicine, National University of Singapore
Ding Ming Whee: Yong Loo Lin School of Medicine, National University of Singapore
Federico Torta: Yong Loo Lin School of Medicine, National University of Singapore
Amaury Cazenave-Gassiot: Yong Loo Lin School of Medicine, National University of Singapore
Takayoshi Matsumura: Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore
Sangho Kim: National University of Singapore
Sue-Anne E. S. Toh: Yong Loo Lin School of Medicine, National University of Singapore
Toshio Suda: Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore
David L. Silver: Signature Research Program in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School
Markus R. Wenk: Yong Loo Lin School of Medicine, National University of Singapore
Long N. Nguyen: Yong Loo Lin School of Medicine, National University of Singapore

Nature, 2017, vol. 550, issue 7677, 524-528

Abstract: Identification of a transmembrane protein, Mfsd2b, that is essential for the export of the signalling molecule sphingosine-1-phosphate (S1P) from red blood cells and platelets.

Date: 2017
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DOI: 10.1038/nature24053

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