Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus

Ming Jiang, Haiyan Li, Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu, Jian Zhu, Zhongren Zhou, Jianming Xu, Dong-Kee Lee, Lanjing Zhang, Yuan-Cho Lee, Jingsong Yuan, Julian A. Abrams, Timothy C. Wang, Antonia R. Sepulveda, Qi Wu, Huaiyong Chen, Xin Sun, Junjun She, Xiaoxin Chen and Jianwen Que ()
Additional contact information
Ming Jiang: Columbia University Medical Center
Haiyan Li: Columbia University Medical Center
Yongchun Zhang: Columbia University Medical Center
Ying Yang: Columbia University Medical Center
Rong Lu: Columbia University Medical Center
Kuancan Liu: Columbia University Medical Center
Sijie Lin: Columbia University Medical Center
Xiaopeng Lan: Institute for Laboratory Medicine, Fuzhou General Hospital
Haikun Wang: CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
Han Wu: Ascendas Genomics Inc.
Jian Zhu: School of Medicine and Dentistry, University of Rochester
Zhongren Zhou: School of Medicine and Dentistry, University of Rochester
Jianming Xu: Baylor College of Medicine
Dong-Kee Lee: Baylor College of Medicine
Lanjing Zhang: University Medical Center of Princeton at Plainsboro
Yuan-Cho Lee: Columbia University Medical Center
Jingsong Yuan: Columbia University Medical Center
Julian A. Abrams: Columbia University Medical Center
Timothy C. Wang: Columbia University Medical Center
Antonia R. Sepulveda: Columbia University Medical Center
Qi Wu: Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University
Huaiyong Chen: Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University
Xin Sun: Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University
Junjun She: First Affiliated Hospital of Medical College, Xi’an Jiaotong University
Xiaoxin Chen: Biomedical/Biotechnology Research Institute, North Carolina Central University
Jianwen Que: Columbia University Medical Center

Nature, 2017, vol. 550, issue 7677, 529-533

Abstract: Barrett’s oesophagus—a metaplasia that can be induced by persistent acid reflux, and predisposes patients to oesophageal cancer—arises from a population of basal cells at the gastro-oesophageal junction.

Date: 2017
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DOI: 10.1038/nature24269

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