Glucose feeds the TCA cycle via circulating lactate

Sheng Hui, Jonathan M. Ghergurovich, Raphael J. Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A. Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen White and Joshua D. Rabinowitz ()
Additional contact information
Sheng Hui: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Jonathan M. Ghergurovich: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Raphael J. Morscher: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Cholsoon Jang: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Xin Teng: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Wenyun Lu: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Lourdes A. Esparza: Moores Cancer Center, University of California San Diego School of Medicine
Tannishtha Reya: Moores Cancer Center, University of California San Diego School of Medicine
Le Zhan: Rutgers Cancer Institute of New Jersey
Jessie Yanxiang Guo: Rutgers Cancer Institute of New Jersey
Eileen White: Rutgers Cancer Institute of New Jersey
Joshua D. Rabinowitz: Lewis-Sigler Institute for Integrative Genomics, Princeton University

Nature, 2017, vol. 551, issue 7678, 115-118

Abstract: Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (8)

Downloads: (external link)
https://www.nature.com/articles/nature24057 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24057

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature24057

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().