Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

Song Zhang, Motoki Takaku, Liyun Zou, Ai-di Gu, Wei-chun Chou, Ge Zhang, Bing Wu, Qing Kong, Seddon Y. Thomas, Jonathan S. Serody, Xian Chen, Xiaojiang Xu, Paul A. Wade, Donald N. Cook, Jenny P. Y. Ting and Yisong Y. Wan ()
Additional contact information
Song Zhang: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Motoki Takaku: Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park
Liyun Zou: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Ai-di Gu: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Wei-chun Chou: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Ge Zhang: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Bing Wu: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Qing Kong: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Seddon Y. Thomas: Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park
Jonathan S. Serody: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Xian Chen: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Xiaojiang Xu: Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park
Paul A. Wade: Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park
Donald N. Cook: Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park
Jenny P. Y. Ting: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Yisong Y. Wan: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Nature, 2017, vol. 551, issue 7678, 105-109

Abstract: TGFβ signalling regulates T helper 17 (TH17) cell differentiation by reversing SKI–SMAD4-mediated suppression of RORγt, revealing a potential therapeutic target for treating TH17-related diseases.

Date: 2017
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DOI: 10.1038/nature24283

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