IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, Sébastien Jaillon, Branka Popović, Giovanni Bernardini, Elena Magrini, Francesca Gianni, Santiago Zelenay, Stipan Jonjić, Angela Santoni, Cecilia Garlanda () and Alberto Mantovani ()
Additional contact information
Martina Molgora: Humanitas Clinical and Research Center
Eduardo Bonavita: Humanitas Clinical and Research Center
Andrea Ponzetta: Humanitas Clinical and Research Center
Federica Riva: Faculty of Veterinary Medicine, University of Milan
Marialuisa Barbagallo: Humanitas Clinical and Research Center
Sébastien Jaillon: Humanitas Clinical and Research Center
Branka Popović: Faculty of Medicine, University of Rijeka
Giovanni Bernardini: Università di Roma “La Sapienza”
Elena Magrini: Humanitas Clinical and Research Center
Francesca Gianni: Humanitas Clinical and Research Center
Santiago Zelenay: Cancer Research UK Manchester Institute, The University of Manchester
Stipan Jonjić: Faculty of Medicine, University of Rijeka
Angela Santoni: Università di Roma “La Sapienza”
Cecilia Garlanda: Humanitas Clinical and Research Center
Alberto Mantovani: Humanitas Clinical and Research Center

Nature, 2017, vol. 551, issue 7678, 110-114

Abstract: Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell activation and that its blockade may be of use in cancer therapy.

Date: 2017
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DOI: 10.1038/nature24293

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