Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte

Ziqing Liu, Li Wang, Joshua D. Welch, Hong Ma, Yang Zhou, Haley Ruth Vaseghi, Shuo Yu, Joseph Blake Wall, Sahar Alimohamadi, Michael Zheng, Chaoying Yin, Weining Shen, Jan F. Prins, Jiandong Liu () and Li Qian ()
Additional contact information
Ziqing Liu: McAllister Heart Institute, University of North Carolina at Chapel Hill
Li Wang: McAllister Heart Institute, University of North Carolina at Chapel Hill
Joshua D. Welch: University of North Carolina at Chapel Hill
Hong Ma: McAllister Heart Institute, University of North Carolina at Chapel Hill
Yang Zhou: McAllister Heart Institute, University of North Carolina at Chapel Hill
Haley Ruth Vaseghi: McAllister Heart Institute, University of North Carolina at Chapel Hill
Shuo Yu: McAllister Heart Institute, University of North Carolina at Chapel Hill
Joseph Blake Wall: McAllister Heart Institute, University of North Carolina at Chapel Hill
Sahar Alimohamadi: McAllister Heart Institute, University of North Carolina at Chapel Hill
Michael Zheng: McAllister Heart Institute, University of North Carolina at Chapel Hill
Chaoying Yin: McAllister Heart Institute, University of North Carolina at Chapel Hill
Weining Shen: University of California at Irvine
Jan F. Prins: University of North Carolina at Chapel Hill
Jiandong Liu: McAllister Heart Institute, University of North Carolina at Chapel Hill
Li Qian: McAllister Heart Institute, University of North Carolina at Chapel Hill

Nature, 2017, vol. 551, issue 7678, 100-104

Abstract: Single-cell transcriptomics analyses of cell intermediates during the reprogramming from fibroblast to cardiomyocyte were used to reconstruct the reprogramming trajectory and to uncover intermediate cell populations, gene pathways and regulators involved in this process.

Date: 2017
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DOI: 10.1038/nature24454

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