Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer, Vasanthi S. Viswanathan, Matthew J. Ryan, Dhruv Bole, John K. Eaton, Alexandre Matov, Jacqueline Galeas, Harshil D. Dhruv, Michael E. Berens, Stuart L. Schreiber, Frank McCormick () and Michael T. McManus ()
Additional contact information
Matthew J. Hangauer: University of California San Francisco
Vasanthi S. Viswanathan: Broad Institute
Matthew J. Ryan: Broad Institute
Dhruv Bole: UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
John K. Eaton: Broad Institute
Alexandre Matov: DataSet Analysis LLC
Jacqueline Galeas: UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Harshil D. Dhruv: The Translational Genomics Research Institute
Michael E. Berens: The Translational Genomics Research Institute
Stuart L. Schreiber: Broad Institute
Frank McCormick: UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Michael T. McManus: University of California San Francisco

Nature, 2017, vol. 551, issue 7679, 247-250

Abstract: Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4.

Date: 2017
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DOI: 10.1038/nature24297

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