BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Simon Raffel, Mattia Falcone, Niclas Kneisel, Jenny Hansson, Wei Wang, Christoph Lutz, Lars Bullinger, Gernot Poschet, Yannic Nonnenmacher, Andrea Barnert, Carsten Bahr, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Martje Tönjes, Ayelet Erez, Lital Adler, Patrizia Jensen, Claudia Scholl, Stefan Fröhling, Sibylle Cocciardi, Patrick Wuchter, Christian Thiede, Anne Flörcken, Jörg Westermann, Gerhard Ehninger, Peter Lichter, Karsten Hiller, Rüdiger Hell, Carl Herrmann, Anthony D. Ho, Jeroen Krijgsveld, Bernhard Radlwimmer () and Andreas Trumpp ()
Additional contact information
Simon Raffel: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
Mattia Falcone: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
Niclas Kneisel: German Cancer Research Center (DKFZ)
Jenny Hansson: Genome Biology Unit, European Molecular Biology Laboratory (EMBL)
Wei Wang: German Cancer Research Center (DKFZ)
Christoph Lutz: Heidelberg University Hospital
Lars Bullinger: University Hospital Ulm
Gernot Poschet: Centre for Organismal Studies (COS), University of Heidelberg
Yannic Nonnenmacher: Technical University Braunschweig
Andrea Barnert: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
Carsten Bahr: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
Petra Zeisberger: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
Adriana Przybylla: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
Markus Sohn: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
Martje Tönjes: German Cancer Research Center (DKFZ)
Ayelet Erez: Weizmann Institute of Science
Lital Adler: Weizmann Institute of Science
Patrizia Jensen: National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
Claudia Scholl: German Cancer Research Center (DKFZ)
Stefan Fröhling: National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
Sibylle Cocciardi: University Hospital Ulm
Patrick Wuchter: Heidelberg University Hospital
Christian Thiede: University Hospital Carl Gustav Carus
Anne Flörcken: Oncology and Tumor Immunology; Charité-University Medicine Berlin, Campus Virchow Klinikum
Jörg Westermann: Oncology and Tumor Immunology; Charité-University Medicine Berlin, Campus Virchow Klinikum
Gerhard Ehninger: Oncology and Tumor Immunology; Charité-University Medicine Berlin, Campus Virchow Klinikum
Peter Lichter: German Cancer Research Center (DKFZ)
Karsten Hiller: Technical University Braunschweig
Rüdiger Hell: Centre for Organismal Studies (COS), University of Heidelberg
Carl Herrmann: German Cancer Research Center (DKFZ)
Anthony D. Ho: Heidelberg University Hospital
Jeroen Krijgsveld: Genome Biology Unit, European Molecular Biology Laboratory (EMBL)
Bernhard Radlwimmer: German Cancer Research Center (DKFZ)
Andreas Trumpp: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)

Nature, 2017, vol. 551, issue 7680, 384-388

Abstract: The mechanistic basis for the role of the metabolic enzyme BCAA transaminase 1 (BCAT1) in acute myeloid leukaemias.

Date: 2017
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DOI: 10.1038/nature24294

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