Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Shabnam Shalapour (), Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee and Michael Karin ()
Additional contact information
Shabnam Shalapour: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Xue-Jia Lin: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Ingmar N. Bastian: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
John Brain: Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University
Alastair D. Burt: Faculty of Health and Medical Sciences, University of Adelaide
Alexander A. Aksenov: Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD)
Alison F. Vrbanac: University of California San Diego (UCSD)
Weihua Li: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Andres Perkins: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Takaji Matsutani: Repertoire Genesis Incorporation
Zhenyu Zhong: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Debanjan Dhar: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Jose A. Navas-Molina: University of California San Diego (UCSD)
Jun Xu: University of California San Diego (UCSD)
Rohit Loomba: NAFLD Research Center, University of California San Diego (UCSD)
Michael Downes: Gene Expression Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies
Ruth T. Yu: Gene Expression Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies
Ronald M. Evans: Gene Expression Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies
Pieter C. Dorrestein: Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD)
Rob Knight: University of California San Diego (UCSD)
Christopher Benner: University of California San Diego (UCSD)
Quentin M. Anstee: Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University
Michael Karin: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)

Nature, 2017, vol. 551, issue 7680, 340-345

Abstract: IgA+ B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty liver disease where they promote the progression to hepatocellular carcinoma by limiting the local activation of PD-1-expressing CD8+ T cells.

Date: 2017
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DOI: 10.1038/nature24302

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