Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

Peng Li, Wei Jiang, Qin Yu, Wang Liu, Ping Zhou, Jun Li, Junjie Xu, Bo Xu, Fengchao Wang and Feng Shao ()
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Peng Li: Peking University–Tsinghua University–National Institute of Biological Sciences Joint Graduate Program, National Institute of Biological Sciences
Wei Jiang: National Institute of Biological Sciences
Qin Yu: National Institute of Biological Sciences
Wang Liu: National Institute of Biological Sciences
Ping Zhou: National Institute of Biological Sciences
Jun Li: National Institute of Biological Sciences
Junjie Xu: National Institute of Biological Sciences
Bo Xu: National Institute of Biological Sciences
Fengchao Wang: National Institute of Biological Sciences
Feng Shao: National Institute of Biological Sciences

Nature, 2017, vol. 551, issue 7680, 378-383

Abstract: A Shigella flexneri type III secretion system effector targets cellular proteins for degradation via the ubiquitin/proteasome pathway, suggesting that such effectors help to overcome defences against bacterial infection.

Date: 2017
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DOI: 10.1038/nature24467

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