A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

Joshua R. Brickner, Jennifer M. Soll, Patrick M. Lombardi, Cathrine B. Vågbø, Miranda C. Mudge, Clement Oyeniran, Renana Rabe, Jessica Jackson, Meagan E. Sullender, Elyse Blazosky, Andrea K. Byrum, Yu Zhao, Mark A. Corbett, Jozef Gécz, Michael Field, Alessandro Vindigni, Geir Slupphaug, Cynthia Wolberger and Nima Mosammaparast ()
Additional contact information
Joshua R. Brickner: Washington University School of Medicine
Jennifer M. Soll: Washington University School of Medicine
Patrick M. Lombardi: Johns Hopkins University School of Medicine
Cathrine B. Vågbø: Norwegian University of Science and Technology
Miranda C. Mudge: Washington University School of Medicine
Clement Oyeniran: Washington University School of Medicine
Renana Rabe: Norwegian University of Science and Technology
Jessica Jackson: St. Louis University School of Medicine
Meagan E. Sullender: Washington University School of Medicine
Elyse Blazosky: Johns Hopkins University School of Medicine
Andrea K. Byrum: Washington University School of Medicine
Yu Zhao: Washington University School of Medicine
Mark A. Corbett: Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide
Jozef Gécz: Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide
Michael Field: Genetics of Learning Disability Service, Hunter Genetics
Alessandro Vindigni: St. Louis University School of Medicine
Geir Slupphaug: Norwegian University of Science and Technology
Cynthia Wolberger: Johns Hopkins University School of Medicine
Nima Mosammaparast: Washington University School of Medicine

Nature, 2017, vol. 551, issue 7680, 389-393

Abstract: A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

Date: 2017
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DOI: 10.1038/nature24484

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