Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Vinod P. Balachandran (), Marta Łuksza, Julia N. Zhao, Vladimir Makarov, John Alec Moral, Romain Remark, Brian Herbst, Gokce Askan, Umesh Bhanot, Yasin Senbabaoglu, Daniel K. Wells, Charles Ian Ormsby Cary, Olivera Grbovic-Huezo, Marc Attiyeh, Benjamin Medina, Jennifer Zhang, Jennifer Loo, Joseph Saglimbeni, Mohsen Abu-Akeel, Roberta Zappasodi, Nadeem Riaz, Martin Smoragiewicz, Z. Larkin Kelley, Olca Basturk, Mithat Gönen, Arnold J. Levine, Peter J. Allen, Douglas T. Fearon, Miriam Merad, Sacha Gnjatic, Christine A. Iacobuzio-Donahue, Jedd D. Wolchok, Ronald P. DeMatteo, Timothy A. Chan, Benjamin D. Greenbaum, Taha Merghoub and Steven D. Leach
Additional contact information
Vinod P. Balachandran: Memorial Sloan Kettering Cancer Center
Marta Łuksza: The Simons Center for Systems Biology, Institute for Advanced Study
Julia N. Zhao: Memorial Sloan Kettering Cancer Center
Vladimir Makarov: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
John Alec Moral: Memorial Sloan Kettering Cancer Center
Romain Remark: Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai
Brian Herbst: David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
Gokce Askan: David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
Umesh Bhanot: Memorial Sloan Kettering Cancer Center
Yasin Senbabaoglu: Swim Across America/Ludwig Collaborative Laboratory
Daniel K. Wells: Parker Institute for Cancer Immunotherapy
Charles Ian Ormsby Cary: Parker Institute for Cancer Immunotherapy
Olivera Grbovic-Huezo: David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
Marc Attiyeh: Memorial Sloan Kettering Cancer Center
Benjamin Medina: Memorial Sloan Kettering Cancer Center
Jennifer Zhang: Memorial Sloan Kettering Cancer Center
Jennifer Loo: Memorial Sloan Kettering Cancer Center
Joseph Saglimbeni: David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
Mohsen Abu-Akeel: Swim Across America/Ludwig Collaborative Laboratory
Roberta Zappasodi: Swim Across America/Ludwig Collaborative Laboratory
Nadeem Riaz: Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center
Martin Smoragiewicz: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
Z. Larkin Kelley: Cold Spring Harbor Laboratory
Olca Basturk: Memorial Sloan Kettering Cancer Center
Mithat Gönen: Memorial Sloan Kettering Cancer Center
Arnold J. Levine: The Simons Center for Systems Biology, Institute for Advanced Study
Peter J. Allen: Memorial Sloan Kettering Cancer Center
Douglas T. Fearon: Cold Spring Harbor Laboratory
Miriam Merad: Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai
Sacha Gnjatic: Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai
Christine A. Iacobuzio-Donahue: David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
Jedd D. Wolchok: Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
Ronald P. DeMatteo: Memorial Sloan Kettering Cancer Center
Timothy A. Chan: Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
Benjamin D. Greenbaum: Tisch Cancer Institute, Hematology and Medical Oncology, Oncological Sciences, and Pathology, Icahn School of Medicine at Mount Sinai
Taha Merghoub: Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
Steven D. Leach: Memorial Sloan Kettering Cancer Center

Nature, 2017, vol. 551, issue 7681, 512-516

Abstract: The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.

Date: 2017
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DOI: 10.1038/nature24462

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