A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage

K. Adam Bohnert and Cynthia Kenyon ()
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K. Adam Bohnert: University of California, San Francisco
Cynthia Kenyon: University of California, San Francisco

Nature, 2017, vol. 551, issue 7682, 629-633

Abstract: Sperm-activated lysosomes enhance proteostasis in nematode oocytes just before fertilization; this could prevent transmission of damaged proteins to the next generation and may explain the immortality of the germ-cell lineage.

Date: 2017
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DOI: 10.1038/nature24620

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