NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Samantha W. Alvarez, Vladislav O. Sviderskiy, Erdem M. Terzi, Thales Papagiannakopoulos, Andre L. Moreira, Sylvia Adams, David M. Sabatini (), Kıvanç Birsoy () and Richard Possemato ()
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Samantha W. Alvarez: New York University School of Medicine
Vladislav O. Sviderskiy: New York University School of Medicine
Erdem M. Terzi: New York University School of Medicine
Thales Papagiannakopoulos: New York University School of Medicine
Andre L. Moreira: New York University School of Medicine
Sylvia Adams: New York University School of Medicine
David M. Sabatini: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Kıvanç Birsoy: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Richard Possemato: New York University School of Medicine

Nature, 2017, vol. 551, issue 7682, 639-643

Abstract: Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.

Date: 2017
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DOI: 10.1038/nature24637

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