A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

Dylan Dodd, Matthew H. Spitzer, William Van Treuren, Bryan D. Merrill, Andrew J. Hryckowian, Steven K. Higginbottom, Anthony Le, Tina M. Cowan, Garry P. Nolan, Michael A. Fischbach () and Justin L. Sonnenburg ()
Additional contact information
Dylan Dodd: Stanford University School of Medicine
Matthew H. Spitzer: Stanford University School of Medicine
William Van Treuren: Stanford University School of Medicine
Bryan D. Merrill: Stanford University School of Medicine
Andrew J. Hryckowian: Stanford University School of Medicine
Steven K. Higginbottom: Stanford University School of Medicine
Anthony Le: Stanford University School of Medicine
Tina M. Cowan: Stanford University School of Medicine
Garry P. Nolan: Stanford University School of Medicine
Michael A. Fischbach: University of California, San Francisco
Justin L. Sonnenburg: Stanford University School of Medicine

Nature, 2017, vol. 551, issue 7682, 648-652

Abstract: A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity.

Date: 2017
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DOI: 10.1038/nature24661

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