Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Giovanni Germano, Simona Lamba, Giuseppe Rospo, Ludovic Barault, Alessandro Magrì, Federica Maione, Mariangela Russo, Giovanni Crisafulli, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Federica Morano, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio D’Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi, Salvatore Siena, Filippo Pietrantonio, Federica Di Nicolantonio and Alberto Bardelli ()
Additional contact information
Giovanni Germano: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Simona Lamba: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Giuseppe Rospo: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Ludovic Barault: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Alessandro Magrì: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Federica Maione: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Mariangela Russo: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Giovanni Crisafulli: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Alice Bartolini: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Giulia Lerda: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Giulia Siravegna: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Benedetta Mussolin: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Roberta Frapolli: IRCCS-Istituto di Ricerche Farmacologiche Mario Negri
Monica Montone: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Federica Morano: Fondazione IRCCS Istituto Nazionale dei Tumori
Filippo de Braud: Fondazione IRCCS Istituto Nazionale dei Tumori
Nabil Amirouchene-Angelozzi: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Silvia Marsoni: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Maurizio D’Incalci: IRCCS-Istituto di Ricerche Farmacologiche Mario Negri
Armando Orlandi: Policlinico Universitario A. Gemelli
Enrico Giraudo: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Andrea Sartore-Bianchi: Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda
Salvatore Siena: Department of Oncology and Hemat-Oncology Università degli Studi di Milano
Filippo Pietrantonio: Fondazione IRCCS Istituto Nazionale dei Tumori
Federica Di Nicolantonio: Candiolo Cancer Institute – FPO, IRCCS, Candiolo
Alberto Bardelli: Candiolo Cancer Institute – FPO, IRCCS, Candiolo

Nature, 2017, vol. 552, issue 7683, 116-120

Abstract: The inactivation of DNA mismatch repair in cancer cells produces dynamic mutational profiles and generates neoantigens, which result in improved immune surveillance against these cells.

Date: 2017
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DOI: 10.1038/nature24673

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