IL-11 is a crucial determinant of cardiovascular fibrosis

Sebastian Schafer, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Aida Moreno-Moral, Daniel M. DeLaughter, Benjamin Ng, Giannino Patone, Kingsley Chow, Ester Khin, Jessie Tan, Sonia P. Chothani, Lei Ye, Owen J. L. Rackham, Nicole S. J. Ko, Norliza E. Sahib, Chee Jian Pua, Nicole T. G. Zhen, Chen Xie, Mao Wang, Henrike Maatz, Shiqi Lim, Kathrin Saar, Susanne Blachut, Enrico Petretto, Sabine Schmidt, Tracy Putoczki, Nuno Guimarães-Camboa, Hiroko Wakimoto, Sebastiaan van Heesch, Kristmundur Sigmundsson, See L. Lim, Jia L. Soon, Victor T. T. Chao, Yeow L. Chua, Teing E. Tan, Sylvia M. Evans, Yee J. Loh, Muhammad H. Jamal, Kim K. Ong, Kim C. Chua, Boon-Hean Ong, Mathew J. Chakaramakkil, Jonathan G. Seidman, Christine E. Seidman, Norbert Hubner, Kenny Y. K. Sin and Stuart A. Cook ()
Additional contact information
Sebastian Schafer: National Heart Centre Singapore
Sivakumar Viswanathan: Duke–National University of Singapore Medical School
Anissa A. Widjaja: Duke–National University of Singapore Medical School
Wei-Wen Lim: National Heart Centre Singapore
Aida Moreno-Moral: Duke–National University of Singapore Medical School
Daniel M. DeLaughter: Harvard Medical School
Benjamin Ng: National Heart Centre Singapore
Giannino Patone: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Kingsley Chow: National Heart Centre Singapore
Ester Khin: Duke–National University of Singapore Medical School
Jessie Tan: National Heart Centre Singapore
Sonia P. Chothani: Duke–National University of Singapore Medical School
Lei Ye: National Heart Centre Singapore
Owen J. L. Rackham: Duke–National University of Singapore Medical School
Nicole S. J. Ko: Duke–National University of Singapore Medical School
Norliza E. Sahib: Duke–National University of Singapore Medical School
Chee Jian Pua: National Heart Centre Singapore
Nicole T. G. Zhen: National Heart Centre Singapore
Chen Xie: National Heart Centre Singapore
Mao Wang: Duke–National University of Singapore Medical School
Henrike Maatz: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Shiqi Lim: National Heart Centre Singapore
Kathrin Saar: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Susanne Blachut: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Enrico Petretto: Duke–National University of Singapore Medical School
Sabine Schmidt: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Tracy Putoczki: Walter and Eliza Hall Institute of Medical Research
Nuno Guimarães-Camboa: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
Hiroko Wakimoto: Harvard Medical School
Sebastiaan van Heesch: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Kristmundur Sigmundsson: Duke–National University of Singapore Medical School
See L. Lim: National Heart Centre Singapore
Jia L. Soon: National Heart Centre Singapore
Victor T. T. Chao: National Heart Centre Singapore
Yeow L. Chua: National Heart Centre Singapore
Teing E. Tan: National Heart Centre Singapore
Sylvia M. Evans: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
Yee J. Loh: National Heart Centre Singapore
Muhammad H. Jamal: National Heart Centre Singapore
Kim K. Ong: National Heart Centre Singapore
Kim C. Chua: National Heart Centre Singapore
Boon-Hean Ong: National Heart Centre Singapore
Mathew J. Chakaramakkil: National Heart Centre Singapore
Jonathan G. Seidman: Harvard Medical School
Christine E. Seidman: Harvard Medical School
Norbert Hubner: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
Kenny Y. K. Sin: National Heart Centre Singapore
Stuart A. Cook: National Heart Centre Singapore

Nature, 2017, vol. 552, issue 7683, 110-115

Abstract: Fibroblast-specific Il-11 expression causes heart and kidney fibrosis and organ failure, whereas IL-11 inhibition prevents fibroblast activation and organ fibrosis, indicating that IL-11 inhibition is a potential therapeutic strategy to treat fibrotic diseases.

Date: 2017
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DOI: 10.1038/nature24676

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