Force loading explains spatial sensing of ligands by cells

Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam () and Pere Roca-Cusachs ()
Additional contact information
Roger Oria: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Tina Wiegand: Max Planck Institute for Medical Research
Jorge Escribano: Aragon Institute of Engineering Research (I3A), University of Zaragoza
Alberto Elosegui-Artola: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Juan Jose Uriarte: University of Barcelona
Cristian Moreno-Pulido: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Ilia Platzman: Max Planck Institute for Medical Research
Pietro Delcanale: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Lorenzo Albertazzi: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Daniel Navajas: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Xavier Trepat: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
José Manuel García-Aznar: Aragon Institute of Engineering Research (I3A), University of Zaragoza
Elisabetta Ada Cavalcanti-Adam: Max Planck Institute for Medical Research
Pere Roca-Cusachs: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)

Nature, 2017, vol. 552, issue 7684, 219-224

Abstract: The formation of cellular adhesion complexes is important in normal and pathological cell activity, and is determined by the force imposed by the combined effect of the distribution of extracellular matrix molecules and substrate rigidity.

Date: 2017
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DOI: 10.1038/nature24662

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