Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaelle Recher, Meng Zhu, Agnieszka Jedrusik, Liani G. Devito, Laila Noli, Iain C. Macaulay, Christa Buecker, Yakoub Khalaf, Dusko Ilic, Thierry Voet, John C. Marioni and Magdalena Zernicka-Goetz ()
Additional contact information
Marta N. Shahbazi: Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street
Antonio Scialdone: EMBL-European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
Natalia Skorupska: Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street
Antonia Weberling: Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street
Gaelle Recher: Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street
Meng Zhu: Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street
Agnieszka Jedrusik: Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street
Liani G. Devito: Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond
Laila Noli: Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond
Iain C. Macaulay: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Christa Buecker: Stanford University School of Medicine, Stanford
Yakoub Khalaf: Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond
Dusko Ilic: Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond
Thierry Voet: Wellcome Trust Sanger Institute, Wellcome Genome Campus
John C. Marioni: EMBL-European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
Magdalena Zernicka-Goetz: Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street

Nature, 2017, vol. 552, issue 7684, 239-243

Abstract: Exit of epiblasts from an unrestricted naive pluripotent state is required for epithelialization and generation of the pro-amniotic cavity in mouse embryos and for amniotic cavity formation in human embryos and human embryonic stem cells.

Date: 2017
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DOI: 10.1038/nature24675

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