A non-canonical Notch complex regulates adherens junctions and vascular barrier function

William J. Polacheck, Matthew L. Kutys, Jinling Yang, Jeroen Eyckmans, Yinyu Wu, Hema Vasavada, Karen K. Hirschi and Christopher S. Chen ()
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William J. Polacheck: The Wyss Institute for Biologically Inspired Engineering, Harvard University
Matthew L. Kutys: The Wyss Institute for Biologically Inspired Engineering, Harvard University
Jinling Yang: The Wyss Institute for Biologically Inspired Engineering, Harvard University
Jeroen Eyckmans: The Wyss Institute for Biologically Inspired Engineering, Harvard University
Yinyu Wu: Yale Cardiovascular Research Center, Genetics, and Biomedical Engineering
Hema Vasavada: Yale Cardiovascular Research Center, Genetics, and Biomedical Engineering
Karen K. Hirschi: Yale Cardiovascular Research Center, Genetics, and Biomedical Engineering
Christopher S. Chen: The Wyss Institute for Biologically Inspired Engineering, Harvard University

Nature, 2017, vol. 552, issue 7684, 258-262

Abstract: The transmembrane domain of NOTCH1 plays a key role in the assembly of adherens junctions and the non-transcriptional regulation of vascular permeability that links transcriptional programs with adhesive and cytoskeletal remodelling.

Date: 2017
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DOI: 10.1038/nature24998

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