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RNA polymerase III limits longevity downstream of TORC1

Danny Filer, Maximillian A. Thompson, Vakil Takhaveev, Adam J. Dobson, Ilektra Kotronaki, James W. M. Green, Matthias Heinemann, Jennifer M. A. Tullet () and Nazif Alic ()
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Danny Filer: Institute of Healthy Ageing, Evolution and Environment, University College London
Maximillian A. Thompson: School of Biosciences, University of Kent
Vakil Takhaveev: Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Adam J. Dobson: Institute of Healthy Ageing, Evolution and Environment, University College London
Ilektra Kotronaki: Institute of Healthy Ageing, Evolution and Environment, University College London
James W. M. Green: School of Biosciences, University of Kent
Matthias Heinemann: Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Jennifer M. A. Tullet: School of Biosciences, University of Kent
Nazif Alic: Institute of Healthy Ageing, Evolution and Environment, University College London

Nature, 2017, vol. 552, issue 7684, 263-267

Abstract: RNA polymerase III is a key evolutionarily conserved regulator of longevity that may have potential as a therapeutic target for age-related conditions.

Date: 2017
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DOI: 10.1038/nature25007

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