Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

Jiong Hu, Sarah Dziumbla, Jihong Lin, Sofia-Iris Bibli, Sven Zukunft, Julian de Mos, Khader Awwad, Timo Frömel, Andreas Jungmann, Kavi Devraj, Zhixing Cheng, Liya Wang, Sascha Fauser, Charles G. Eberhart, Akrit Sodhi, Bruce D. Hammock, Stefan Liebner, Oliver J. Müller, Clemens Glaubitz, Hans-Peter Hammes, Rüdiger Popp and Ingrid Fleming ()
Additional contact information
Jiong Hu: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
Sarah Dziumbla: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
Jihong Lin: University Medicine Mannheim, University of Heidelberg
Sofia-Iris Bibli: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
Sven Zukunft: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
Julian de Mos: Institute for Biophysical Chemistry and Centre for Biomolecular Magnetic Resonance, Goethe University
Khader Awwad: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
Timo Frömel: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
Andreas Jungmann: Internal Medicine III, University Hospital Heidelberg
Kavi Devraj: Institute of Neurology (Edinger-Institute), Goethe University
Zhixing Cheng: Henan Eye Institute & Henan Eye Hospital
Liya Wang: Henan Eye Institute & Henan Eye Hospital
Sascha Fauser: University Hospital of Cologne
Charles G. Eberhart: Wilmer Eye Institute, Johns Hopkins School of Medicine
Akrit Sodhi: Wilmer Eye Institute, Johns Hopkins School of Medicine
Bruce D. Hammock: University of California, Davis
Stefan Liebner: German Centre for Cardiovascular Research (DZHK) partner site Rhein-Main
Oliver J. Müller: Internal Medicine III, University Hospital Heidelberg
Clemens Glaubitz: Institute for Biophysical Chemistry and Centre for Biomolecular Magnetic Resonance, Goethe University
Hans-Peter Hammes: University Medicine Mannheim, University of Heidelberg
Rüdiger Popp: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
Ingrid Fleming: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University

Nature, 2017, vol. 552, issue 7684, 248-252

Abstract: A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature25013 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:552:y:2017:i:7684:d:10.1038_nature25013

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature25013

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().