Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

Cristina Paulino, Valeria Kalienkova, Andy K. M. Lam, Yvonne Neldner and Raimund Dutzler ()
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Cristina Paulino: University of Zurich
Valeria Kalienkova: University of Zurich
Andy K. M. Lam: University of Zurich
Yvonne Neldner: University of Zurich
Raimund Dutzler: University of Zurich

Nature, 2017, vol. 552, issue 7685, 421-425

Abstract: Cryo-electron microscopy mapping of the calcium-activated chloride channel TMEM16A combined with functional experiments reveals that calcium ions interact directly with the pore to activate the channel.

Date: 2017
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DOI: 10.1038/nature24652

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