Effector CD8 T cells dedifferentiate into long-lived memory cells

Ben Youngblood (), J. Scott Hale, Haydn T. Kissick, Eunseon Ahn, Xiaojin Xu, Andreas Wieland, Koichi Araki, Erin E. West, Hazem E. Ghoneim, Yiping Fan, Pranay Dogra, Carl W. Davis, Bogumila T. Konieczny, Rustom Antia, Xiaodong Cheng and Rafi Ahmed ()
Additional contact information
Ben Youngblood: Emory Vaccine Center, Emory University School of Medicine
J. Scott Hale: Emory Vaccine Center, Emory University School of Medicine
Haydn T. Kissick: Emory University School of Medicine
Eunseon Ahn: Emory Vaccine Center, Emory University School of Medicine
Xiaojin Xu: Emory Vaccine Center, Emory University School of Medicine
Andreas Wieland: Emory Vaccine Center, Emory University School of Medicine
Koichi Araki: Emory Vaccine Center, Emory University School of Medicine
Erin E. West: Emory Vaccine Center, Emory University School of Medicine
Hazem E. Ghoneim: St. Jude Children’s Research Hospital
Yiping Fan: St. Jude Children’s Research Hospital
Pranay Dogra: St. Jude Children’s Research Hospital
Carl W. Davis: Emory Vaccine Center, Emory University School of Medicine
Bogumila T. Konieczny: Emory Vaccine Center, Emory University School of Medicine
Rustom Antia: Emory University
Xiaodong Cheng: Emory University School of Medicine
Rafi Ahmed: Emory Vaccine Center, Emory University School of Medicine

Nature, 2017, vol. 552, issue 7685, 404-409

Abstract: DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

Date: 2017
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DOI: 10.1038/nature25144

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