Evolution of a designed protein assembly encapsulating its own RNA genome

Gabriel L. Butterfield, Marc J. Lajoie, Heather H. Gustafson, Drew L. Sellers, Una Nattermann, Daniel Ellis, Jacob B. Bale, Sharon Ke, Garreck H. Lenz, Angelica Yehdego, Rashmi Ravichandran, Suzie H. Pun, Neil P. King and David Baker ()
Additional contact information
Gabriel L. Butterfield: Institute for Protein Design, University of Washington
Marc J. Lajoie: Institute for Protein Design, University of Washington
Heather H. Gustafson: University of Washington
Drew L. Sellers: University of Washington
Una Nattermann: Institute for Protein Design, University of Washington
Daniel Ellis: Institute for Protein Design, University of Washington
Jacob B. Bale: Institute for Protein Design, University of Washington
Sharon Ke: University of Washington
Garreck H. Lenz: College of Arts & Sciences, University of Washington
Angelica Yehdego: School of Public Health, University of Washington
Rashmi Ravichandran: Institute for Protein Design, University of Washington
Suzie H. Pun: University of Washington
Neil P. King: Institute for Protein Design, University of Washington
David Baker: Institute for Protein Design, University of Washington

Nature, 2017, vol. 552, issue 7685, 415-420

Abstract: Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery.

Date: 2017
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DOI: 10.1038/nature25157

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