Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts

Raymond W. Bourdeau, Audrey Lee-Gosselin, Anupama Lakshmanan, Arash Farhadi, Sripriya Ravindra Kumar, Suchita P. Nety and Mikhail G. Shapiro ()
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Raymond W. Bourdeau: California Institute of Technology
Audrey Lee-Gosselin: California Institute of Technology
Anupama Lakshmanan: California Institute of Technology
Arash Farhadi: California Institute of Technology
Sripriya Ravindra Kumar: California Institute of Technology
Suchita P. Nety: California Institute of Technology
Mikhail G. Shapiro: California Institute of Technology

Nature, 2018, vol. 553, issue 7686, 86-90

Abstract: Heterologous expression of engineered gas vesicles allows noninvasive, deep-tissue ultrasound visualization of engineered bacteria in vivo in mouse tumour models and in the gastrointestinal tract.

Date: 2018
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DOI: 10.1038/nature25021

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