Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727

Nathan Robertson, Mathieu Rappas, Andrew S. Doré, Jason Brown, Giovanni Bottegoni, Markus Koglin, Julie Cansfield, Ali Jazayeri, Robert M. Cooke and Fiona H. Marshall ()
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Nathan Robertson: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Mathieu Rappas: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Andrew S. Doré: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Jason Brown: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Giovanni Bottegoni: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Markus Koglin: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Julie Cansfield: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Ali Jazayeri: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Robert M. Cooke: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City
Fiona H. Marshall: Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City

Nature, 2018, vol. 553, issue 7686, 111-114

Abstract: The crystal structure of the complement receptor C5aR1 bound to a small-molecule antagonist provides insights into this receptor class and how they could be better targeted therapeutically.

Date: 2018
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DOI: 10.1038/nature25025

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