Structure of the glucagon receptor in complex with a glucagon analogue

Haonan Zhang, Anna Qiao, Linlin Yang, Ned Van Eps, Klaus S. Frederiksen, Dehua Yang, Antao Dai, Xiaoqing Cai, Hui Zhang, Cuiying Yi, Can Cao, Lingli He, Huaiyu Yang, Jesper Lau, Oliver P. Ernst, Michael A. Hanson, Raymond C. Stevens, Ming-Wei Wang, Steffen Reedtz-Runge, Hualiang Jiang, Qiang Zhao () and Beili Wu ()
Additional contact information
Haonan Zhang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Anna Qiao: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Linlin Yang: School of Basic Medical Sciences, Zhengzhou University
Ned Van Eps: University of Toronto
Klaus S. Frederiksen: Novo Nordisk A/S, Novo Nordisk Park
Dehua Yang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Antao Dai: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xiaoqing Cai: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hui Zhang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Cuiying Yi: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Can Cao: University of Chinese Academy of Sciences
Lingli He: National Laboratory of Biomacromolecules, National Center of Protein Science - Beijing, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Huaiyu Yang: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
Jesper Lau: Novo Nordisk A/S, Novo Nordisk Park
Oliver P. Ernst: University of Toronto
Michael A. Hanson: GPCR Consortium, San Marcos
Raymond C. Stevens: iHuman Institute, ShanghaiTech University
Ming-Wei Wang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Steffen Reedtz-Runge: Novo Nordisk A/S, Novo Nordisk Park
Hualiang Jiang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Qiang Zhao: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Beili Wu: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Nature, 2018, vol. 553, issue 7686, 106-110

Abstract: The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.

Date: 2018
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DOI: 10.1038/nature25153

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