Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Stephen C. Mack, Kristian W. Pajtler, Lukas Chavez, Konstantin Okonechnikov, Kelsey C. Bertrand, Xiuxing Wang, Serap Erkek, Alexander Federation, Anne Song, Christine Lee, Xin Wang, Laura McDonald, James J. Morrow, Alina Saiakhova, Patrick Sin-Chan, Qiulian Wu, Kulandaimanuvel Antony Michaelraj, Tyler E. Miller, Christopher G. Hubert, Marina Ryzhova, Livia Garzia, Laura Donovan, Stephen Dombrowski, Daniel C. Factor, Betty Luu, Claudia L. L. Valentim, Ryan C. Gimple, Andrew Morton, Leo Kim, Briana C. Prager, John J. Y. Lee, Xiaochong Wu, Jennifer Zuccaro, Yuan Thompson, Borja L. Holgado, Jüri Reimand, Susan Q. Ke, Adam Tropper, Sisi Lai, Senthuran Vijayarajah, Sylvia Doan, Vaidehi Mahadev, Ana Fernandez Miñan, Susanne N. Gröbner, Matthias Lienhard, Marc Zapatka, Zhiqin Huang, Kenneth D. Aldape, Angel M. Carcaboso, Peter J. Houghton, Stephen T. Keir, Till Milde, Hendrik Witt, Yan Li, Chao-Jun Li, Xiu-Wu Bian, David T. W. Jones, Ian Scott, Sheila K. Singh, Annie Huang, Peter B. Dirks, Eric Bouffet, James E. Bradner, Vijay Ramaswamy, Nada Jabado, James T. Rutka, Paul A. Northcott, Mathieu Lupien, Peter Lichter, Andrey Korshunov, Peter C. Scacheri, Stefan M. Pfister, Marcel Kool (), Michael D. Taylor () and Jeremy N. Rich ()
Additional contact information
Stephen C. Mack: Baylor College of Medicine
Kristian W. Pajtler: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Lukas Chavez: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Konstantin Okonechnikov: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Kelsey C. Bertrand: Baylor College of Medicine
Xiuxing Wang: Lerner Research Institute, Cleveland Clinic
Serap Erkek: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Alexander Federation: University of Washington
Anne Song: Lerner Research Institute, Cleveland Clinic
Christine Lee: Lerner Research Institute, Cleveland Clinic
Xin Wang: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Laura McDonald: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
James J. Morrow: Case Western Reserve University
Alina Saiakhova: Case Western Reserve University
Patrick Sin-Chan: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Qiulian Wu: Lerner Research Institute, Cleveland Clinic
Kulandaimanuvel Antony Michaelraj: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Tyler E. Miller: Lerner Research Institute, Cleveland Clinic
Christopher G. Hubert: Lerner Research Institute, Cleveland Clinic
Marina Ryzhova: NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16
Livia Garzia: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Laura Donovan: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Stephen Dombrowski: Lerner Research Institute, Cleveland Clinic
Daniel C. Factor: Case Western Reserve University
Betty Luu: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Claudia L. L. Valentim: Lerner Research Institute, Cleveland Clinic
Ryan C. Gimple: Lerner Research Institute, Cleveland Clinic
Andrew Morton: Lerner Research Institute, Cleveland Clinic
Leo Kim: Lerner Research Institute, Cleveland Clinic
Briana C. Prager: Lerner Research Institute, Cleveland Clinic
John J. Y. Lee: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Xiaochong Wu: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Jennifer Zuccaro: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Yuan Thompson: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Borja L. Holgado: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Jüri Reimand: Computational Biology Program, Ontario Institute for Cancer Research
Susan Q. Ke: Lerner Research Institute, Cleveland Clinic
Adam Tropper: Lerner Research Institute, Cleveland Clinic
Sisi Lai: Lerner Research Institute, Cleveland Clinic
Senthuran Vijayarajah: Cleveland Clinic
Sylvia Doan: University of Utah School of Medicine
Vaidehi Mahadev: Lerner Research Institute, Cleveland Clinic
Ana Fernandez Miñan: Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas and Universidad Pablo de Olavide
Susanne N. Gröbner: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Matthias Lienhard: Max-Planck-Institute for Molecular Genetics
Marc Zapatka: German Cancer Research Center (DKFZ)
Zhiqin Huang: German Cancer Research Center (DKFZ)
Kenneth D. Aldape: University Health Network
Angel M. Carcaboso: Preclinical Therapeutics and Drug Delivery Research Program, Fundacio Sant Joan de Deu
Peter J. Houghton: Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases
Stephen T. Keir: Duke University Medical Center
Till Milde: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Hendrik Witt: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Yan Li: Case Western Reserve University
Chao-Jun Li: MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, National Resource Centre for Mutant Mice
Xiu-Wu Bian: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University, and The Key Laboratory of Tumor Immunopathology, The Ministry of Education of China
David T. W. Jones: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Ian Scott: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Sheila K. Singh: Faculty of Health Sciences, McMaster University
Annie Huang: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Peter B. Dirks: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Eric Bouffet: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
James E. Bradner: Novartis Institutes for Biomedical Research
Vijay Ramaswamy: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Nada Jabado: McGill University and the McGill University Health Centre Research Institute
James T. Rutka: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Paul A. Northcott: Developmental Neurobiology, St Jude Children’s Research Hospital
Mathieu Lupien: University of Toronto
Peter Lichter: German Cancer Research Center (DKFZ)
Andrey Korshunov: University of Heidelberg
Peter C. Scacheri: Case Western Reserve University
Stefan M. Pfister: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Marcel Kool: Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
Michael D. Taylor: Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children
Jeremy N. Rich: Lerner Research Institute, Cleveland Clinic

Nature, 2018, vol. 553, issue 7686, 101-105

Abstract: Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.

Date: 2018
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DOI: 10.1038/nature25169

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