A metabolic function of FGFR3-TACC3 gene fusions in cancer

Véronique Frattini, Stefano M. Pagnotta, Tala, Jerry J. Fan, Marco V. Russo, Sang Bae Lee, Luciano Garofano, Jing Zhang, Peiguo Shi, Genevieve Lewis, Heloise Sanson, Vanessa Frederick, Angelica M. Castano, Luigi Cerulo, Delphine C. M. Rolland, Raghvendra Mall, Karima Mokhtari, Kojo S. J. Elenitoba-Johnson, Marc Sanson, Xi Huang, Michele Ceccarelli, Anna Lasorella () and Antonio Iavarone ()
Additional contact information
Véronique Frattini: Institute for Cancer Genetics, Columbia University Medical Center
Stefano M. Pagnotta: Institute for Cancer Genetics, Columbia University Medical Center
Tala: Institute for Cancer Genetics, Columbia University Medical Center
Jerry J. Fan: The Arthur and Sonia Labatt Brain Tumour Research Centre, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
Marco V. Russo: Institute for Cancer Genetics, Columbia University Medical Center
Sang Bae Lee: Institute for Cancer Genetics, Columbia University Medical Center
Luciano Garofano: Institute for Cancer Genetics, Columbia University Medical Center
Jing Zhang: Institute for Cancer Genetics, Columbia University Medical Center
Peiguo Shi: Institute for Cancer Genetics, Columbia University Medical Center
Genevieve Lewis: Institute for Cancer Genetics, Columbia University Medical Center
Heloise Sanson: Institute for Cancer Genetics, Columbia University Medical Center
Vanessa Frederick: Institute for Cancer Genetics, Columbia University Medical Center
Angelica M. Castano: Institute for Cancer Genetics, Columbia University Medical Center
Luigi Cerulo: Universita’ degli Studi del Sannio
Delphine C. M. Rolland: Perelman School of Medicine at University of Pennsylvania
Raghvendra Mall: Qatar Computing Research Institute (QCRI), Hamad Bin Khalifa University
Karima Mokhtari: Sorbonne Universités UPMC Univ Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM
Kojo S. J. Elenitoba-Johnson: Perelman School of Medicine at University of Pennsylvania
Marc Sanson: Sorbonne Universités UPMC Univ Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM
Xi Huang: The Arthur and Sonia Labatt Brain Tumour Research Centre, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
Michele Ceccarelli: Universita’ degli Studi del Sannio
Anna Lasorella: Institute for Cancer Genetics, Columbia University Medical Center
Antonio Iavarone: Institute for Cancer Genetics, Columbia University Medical Center

Nature, 2018, vol. 553, issue 7687, 222-227

Abstract: Oncogenic FGFR3–TACC3 gene fusions signal through phosphorylated PIN4 to trigger biogenesis of peroxisomes and synthesis of new proteins, enabling mitochondrial respiration and tumour growth.

Date: 2018
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DOI: 10.1038/nature25171

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