Precision editing of the gut microbiota ameliorates colitis

Wenhan Zhu, Maria G. Winter, Mariana X. Byndloss, Luisella Spiga, Breck A. Duerkop, Elizabeth R. Hughes, Lisa Büttner, Everton de Lima Romão, Cassie L. Behrendt, Christopher A. Lopez, Luis Sifuentes-Dominguez, Kayci Huff-Hardy, R. Paul Wilson, Caroline C. Gillis, Çagla Tükel, Andrew Y. Koh, Ezra Burstein, Lora V. Hooper, Andreas J. Bäumler () and Sebastian E. Winter ()
Additional contact information
Wenhan Zhu: University of Texas Southwestern Medical Center
Maria G. Winter: University of Texas Southwestern Medical Center
Mariana X. Byndloss: School of Medicine, University of California, Davis, One Shields Avenue
Luisella Spiga: University of Texas Southwestern Medical Center
Breck A. Duerkop: University of Texas Southwestern Medical Center
Elizabeth R. Hughes: University of Texas Southwestern Medical Center
Lisa Büttner: University of Texas Southwestern Medical Center
Everton de Lima Romão: School of Medicine, University of California, Davis, One Shields Avenue
Cassie L. Behrendt: University of Texas Southwestern Medical Center
Christopher A. Lopez: School of Medicine, University of California, Davis, One Shields Avenue
Luis Sifuentes-Dominguez: University of Texas Southwestern Medical Center
Kayci Huff-Hardy: University of Texas Southwestern Medical Center 75390
R. Paul Wilson: Lewis Katz School of Medicine, Temple University
Caroline C. Gillis: University of Texas Southwestern Medical Center
Çagla Tükel: Lewis Katz School of Medicine, Temple University
Andrew Y. Koh: University of Texas Southwestern Medical Center
Ezra Burstein: University of Texas Southwestern Medical Center 75390
Lora V. Hooper: University of Texas Southwestern Medical Center
Andreas J. Bäumler: School of Medicine, University of California, Davis, One Shields Avenue
Sebastian E. Winter: University of Texas Southwestern Medical Center

Nature, 2018, vol. 553, issue 7687, 208-211

Abstract: Tungstate inhibits molybdenum-cofactor-dependent microbial respiratory pathways and shows potential as a selective treatment for microbial imbalances that occur during inflammation of the gastrointestinal tract.

Date: 2018
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DOI: 10.1038/nature25172

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