Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

Gabriele Sulli (), Amy Rommel, Xiaojie Wang, Matthew J. Kolar, Francesca Puca, Alan Saghatelian, Maksim V. Plikus, Inder M. Verma and Satchidananda Panda ()
Additional contact information
Gabriele Sulli: Regulatory Biology Laboratory, Salk Institute for Biological Studies
Amy Rommel: Laboratory of Genetics, Salk Institute for Biological Studies
Xiaojie Wang: University of California, Irvine
Matthew J. Kolar: Clayton Foundation Laboratories of Peptide Biology, Salk Institute for Biological Studies
Francesca Puca: The University of Texas MD, Anderson Cancer Center
Alan Saghatelian: Clayton Foundation Laboratories of Peptide Biology, Salk Institute for Biological Studies
Maksim V. Plikus: University of California, Irvine
Inder M. Verma: Laboratory of Genetics, Salk Institute for Biological Studies
Satchidananda Panda: Regulatory Biology Laboratory, Salk Institute for Biological Studies

Nature, 2018, vol. 553, issue 7688, 351-355

Abstract: REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth in vivo.

Date: 2018
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DOI: 10.1038/nature25170

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