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AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

Martina M. Yordanova, Gary Loughran, Alexander V. Zhdanov, Marco Mariotti, Stephen J. Kiniry, Patrick B. F. O’Connor, Dmitry E. Andreev, Ioanna Tzani, Paul Saffert, Audrey M. Michel, Vadim N. Gladyshev, Dmitry B. Papkovsky, John F. Atkins and Pavel V. Baranov ()
Additional contact information
Martina M. Yordanova: School of Biochemistry and Cell Biology, University College Cork
Gary Loughran: School of Biochemistry and Cell Biology, University College Cork
Alexander V. Zhdanov: School of Biochemistry and Cell Biology, University College Cork
Marco Mariotti: School of Biochemistry and Cell Biology, University College Cork
Stephen J. Kiniry: School of Biochemistry and Cell Biology, University College Cork
Patrick B. F. O’Connor: School of Biochemistry and Cell Biology, University College Cork
Dmitry E. Andreev: School of Biochemistry and Cell Biology, University College Cork
Ioanna Tzani: School of Biochemistry and Cell Biology, University College Cork
Paul Saffert: School of Biochemistry and Cell Biology, University College Cork
Audrey M. Michel: School of Biochemistry and Cell Biology, University College Cork
Vadim N. Gladyshev: Brigham and Women’s Hospital and Harvard Medical School
Dmitry B. Papkovsky: School of Biochemistry and Cell Biology, University College Cork
John F. Atkins: School of Biochemistry and Cell Biology, University College Cork
Pavel V. Baranov: School of Biochemistry and Cell Biology, University College Cork

Nature, 2018, vol. 553, issue 7688, 356-360

Abstract: A regulatory mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding adenosylmethionine decarboxylase 1.

Date: 2018
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DOI: 10.1038/nature25174

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