Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus

Romain Gibeaux, Rachael Acker, Maiko Kitaoka, Georgios Georgiou, Ila van Kruijsbergen, Breanna Ford, Edward M. Marcotte, Daniel K. Nomura, Taejoon Kwon, Gert Jan C. Veenstra and Rebecca Heald ()
Additional contact information
Romain Gibeaux: University of California, Berkeley
Rachael Acker: University of California, Berkeley
Maiko Kitaoka: University of California, Berkeley
Georgios Georgiou: Radboud University, Faculty of Science, Radboud Institute for Molecular Life Sciences
Ila van Kruijsbergen: Radboud University, Faculty of Science, Radboud Institute for Molecular Life Sciences
Breanna Ford: University of California, Berkeley
Edward M. Marcotte: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin
Daniel K. Nomura: University of California, Berkeley
Taejoon Kwon: Ulsan National Institute of Science and Technology
Gert Jan C. Veenstra: Radboud University, Faculty of Science, Radboud Institute for Molecular Life Sciences
Rebecca Heald: University of California, Berkeley

Nature, 2018, vol. 553, issue 7688, 337-341

Abstract: In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis cytoplasm and are mis-segregated during mitosis, leading to unbalanced gene expression at the maternal to zygotic transition, followed by cell-autonomous catastrophic embryo death.

Date: 2018
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DOI: 10.1038/nature25188

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