A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

Carsten Bahr, Lisa von Paleske, Veli V. Uslu, Silvia Remeseiro, Naoya Takayama, Stanley W. Ng, Alex Murison, Katja Langenfeld, Massimo Petretich, Roberta Scognamiglio, Petra Zeisberger, Amelie S. Benk, Ido Amit, Peter W. Zandstra, Mathieu Lupien, John E. Dick, Andreas Trumpp () and François Spitz ()
Additional contact information
Carsten Bahr: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
Lisa von Paleske: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
Veli V. Uslu: Developmental Biology Unit, European Molecular Biology Laboratory (EMBL)
Silvia Remeseiro: Developmental Biology Unit, European Molecular Biology Laboratory (EMBL)
Naoya Takayama: Princess Margaret Cancer Centre, University Health Network
Stanley W. Ng: Institute of Biomaterials and Biomedical Engineering, University of Toronto
Alex Murison: Princess Margaret Cancer Centre, University Health Network
Katja Langenfeld: Developmental Biology Unit, European Molecular Biology Laboratory (EMBL)
Massimo Petretich: Developmental Biology Unit, European Molecular Biology Laboratory (EMBL)
Roberta Scognamiglio: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
Petra Zeisberger: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
Amelie S. Benk: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
Ido Amit: Weizmann Institute of Science
Peter W. Zandstra: Institute of Biomaterials and Biomedical Engineering, University of Toronto
Mathieu Lupien: Princess Margaret Cancer Centre, University Health Network
John E. Dick: Princess Margaret Cancer Centre, University Health Network
Andreas Trumpp: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
François Spitz: Developmental Biology Unit, European Molecular Biology Laboratory (EMBL)

Nature, 2018, vol. 553, issue 7689, 515-520

Abstract: A blood enhancer cluster forms a highly combinatorial system that allows precise control of Myc expression across normal and leukaemic haematopoietic stem-cell hierarchies.

Date: 2018
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DOI: 10.1038/nature25193

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