Regulation of embryonic haematopoietic multipotency by EZH1

Linda T. Vo, Melissa A. Kinney, Xin Liu, Yuannyu Zhang, Jessica Barragan, Patricia M. Sousa, Deepak K. Jha, Areum Han, Marcella Cesana, Zhen Shao, Trista E. North, Stuart H. Orkin, Sergei Doulatov, Jian Xu and George Q. Daley ()
Additional contact information
Linda T. Vo: Stem Cell Program, Boston Children’s Hospital
Melissa A. Kinney: Stem Cell Program, Boston Children’s Hospital
Xin Liu: Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
Yuannyu Zhang: Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
Jessica Barragan: Stem Cell Program, Boston Children’s Hospital
Patricia M. Sousa: Stem Cell Program, Boston Children’s Hospital
Deepak K. Jha: Stem Cell Program, Boston Children’s Hospital
Areum Han: Stem Cell Program, Boston Children’s Hospital
Marcella Cesana: Stem Cell Program, Boston Children’s Hospital
Zhen Shao: Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Trista E. North: Beth Israel-Deaconess Medical Center
Stuart H. Orkin: Boston Children’s Hospital and Dana Farber Cancer Institute
Sergei Doulatov: University of Washington
Jian Xu: Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
George Q. Daley: Stem Cell Program, Boston Children’s Hospital

Nature, 2018, vol. 553, issue 7689, 506-510

Abstract: The production of haematopoietic stem cells is repressed during early mammalian embryogenesis by an epigenetic mechanism that involves the action of the Polycomb protein EZH1.

Date: 2018
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DOI: 10.1038/nature25435

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