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Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication

Xinghong Dai, Danyang Gong, Hanyoung Lim, Jonathan Jih, Ting-Ting Wu, Ren Sun () and Z. Hong Zhou ()
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Xinghong Dai: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
Danyang Gong: University of California, Los Angeles (UCLA)
Hanyoung Lim: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
Jonathan Jih: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
Ting-Ting Wu: University of California, Los Angeles (UCLA)
Ren Sun: The California NanoSystems Institute (CNSI), University of California, Los Angeles (UCLA)
Z. Hong Zhou: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)

Nature, 2018, vol. 553, issue 7689, 521-525

Abstract: Cryo-electron microscopy reveals the structure of the Kaposi’s sarcoma-associated herpesvirus capsid, and experiments with polypeptides that mimic the smallest capsid protein demonstrate the potential for structure-derived insights to help to develop antiviral agents.

Date: 2018
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DOI: 10.1038/nature25438

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