Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication
Xinghong Dai,
Danyang Gong,
Hanyoung Lim,
Jonathan Jih,
Ting-Ting Wu,
Ren Sun () and
Z. Hong Zhou ()
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Xinghong Dai: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
Danyang Gong: University of California, Los Angeles (UCLA)
Hanyoung Lim: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
Jonathan Jih: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
Ting-Ting Wu: University of California, Los Angeles (UCLA)
Ren Sun: The California NanoSystems Institute (CNSI), University of California, Los Angeles (UCLA)
Z. Hong Zhou: Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
Nature, 2018, vol. 553, issue 7689, 521-525
Abstract:
Cryo-electron microscopy reveals the structure of the Kaposi’s sarcoma-associated herpesvirus capsid, and experiments with polypeptides that mimic the smallest capsid protein demonstrate the potential for structure-derived insights to help to develop antiviral agents.
Date: 2018
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DOI: 10.1038/nature25438
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