Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

Qicong Shen, Qian Zhang, Yang Shi, Qingzhu Shi, Yanyan Jiang, Yan Gu, Zhiqing Li, Xia Li, Kai Zhao, Chunmei Wang, Nan Li and Xuetao Cao ()
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Qicong Shen: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Qian Zhang: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Yang Shi: Institute of Immunology, Zhejiang University School of Medicine
Qingzhu Shi: Institute of Immunology, Zhejiang University School of Medicine
Yanyan Jiang: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Yan Gu: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Zhiqing Li: Institute of Immunology, Zhejiang University School of Medicine
Xia Li: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Kai Zhao: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Chunmei Wang: Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Nan Li: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Xuetao Cao: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University

Nature, 2018, vol. 554, issue 7690, 123-127

Abstract: A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level.

Date: 2018
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DOI: 10.1038/nature25434

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